师资

陈永龙
副教授
0755-88018456
chenyl@sustech.edu.cn

个人简介
陈永龙,欧宝ob体育app(中国)有限公司官网,生物系副教授。西北师范大学学士和硕士,德国Essen大学博士。广东省特支计划“百千万工程领军人才”。长期致力于以动物模型进行胰腺发育及胰岛beta细胞再生分子机制等领域的研究,这些研究对糖尿病的细胞移植治疗提供可移植的胰岛细胞具有重要的指导意义。研究项目获得多项国家自然科学基金委、科技部“973计划”、中国科学院“知识创新工程”重要方向项目以及深圳市科创委基础研究项目等的支持。已在Genes & Development、PNAS、EMBO Journal、Development 等期刊上发表论文55篇。

 

研究领域
1. 胰腺发育与再生的分子机理
2. 癌症动物模型

 

工作经历
2014—至今,欧宝ob体育app(中国)有限公司官网,生物系,副教授
2007-2014, 中国科学院广州生物医药与健康研究院,研究员
1999-2007, 德国哥廷根大学医学院博士后
1989-1995, 西北师范大学生物系,助教、讲师

 

教育背景
1999年,获德国Essen大学动物生理系博士学位
1989年,获西北师范大学生物系硕士学位
1986年,获西北师范大学生物系学士学位

 

获奖情况及荣誉
2014年,广东省特支计划“百千万工程领军人才”

 

代表文章
1. Shi, Z., Xin, H., Tian, D., Lian, J., Wang, J., Liu, G., Ran, R., Shi, S., Zhang, Z., Shi, Y., Deng, Y., Hou, C., and Chen, Y. 2019. Modeling human point mutation diseases in Xenopus tropicalis with a modified CRISPR/Cas9 system. FASEB J. 33, 6962-6968.
2. Shi, Z., Tian, D., Xin, H., Lian, J., Guo, X., and Chen, Y. 2017. Targeted integration of genes in Xenopus tropicalis. Genesis 55(1-2).
3. Shi, Z., Wang, F., Cui, Y., Liu, Z., Guo, X., Zhang, Y., Deng, Y., Zhao, H., and Chen, Y. 2015. Heritable CRISPR/Cas9-mediated targeted integration in Xenopus tropicalis. FASEB J.29, 4914-4923.
4. Guo, X., Zhang, T., Hu, Z., Zhang, Y., Shi, Z., Wang, Q., Cui, Y., Wang, F., Zhao, H., and Chen, Y. 2014. Efficient RNA/Cas9-mediated genome editing in Xenopus tropicalis. Development 141, 707-714.
5. Zhao, H., Han, D., Dawid, I.B., Pieler, T., and Chen, Y. 2012. Homeoprotein hhex-induced conversion of intestinal to ventral pancreatic precursors results in the formation of giant pancreata in Xenopus embryos. Proc. Natl. Acad. Sci. U S A. 109,8594-8599.
6. Lei, Y., Guo, X., Liu, Y., Cao, Y., Deng, Y., Chen, X., Cheng, C.H., Dawid, I.B., Chen, Y., and Zhao, H. 2012. Efficient targeted gene disruption in Xenopus embryos using engineered transcription activator-like effector nucleases (TALENs). Proc. Natl. Acad. Sci. U S A. 109, 17484-17489.
7. Wen, L., Yang, Y., Wang, Y., Xu, A., Wu, D., and Chen, Y. 2010. Appl1 is essential for the survival of Xenopus pancreas, duodenum, and stomach progenitor cells. Dev. Dyn. 239, 2198-2207.
8. Afelik, S., Chen, Y. and Pieler, T. 2006. Combined ectopic expression of Pdx1 and Ptf1a/p48 results in the stable conversion of posterior endoderm into endocrine and exocrine pancreatic tissue. Genes Dev. 20, 1441-1446.
9. Chen, Y., Pan, F. C., Brandes, N., Afelik, S., Sölter, M. and Pieler, T. 2004. Retinoic acid signaling is essential for pancreas development and promotes endocrine at the expense of exocrine cell differentiation in Xenopus. Dev. Biol. 271, 144-160.
10. Hollemann, T., Chen, Y., Grunz, H. and Pieler, T. 1998. Regionalized metabolic activity establishes boundaries of retinoic acid signalling. EMBO J. 17, 7361-7372.