师资

肖国芝
教授、医学院科研和研究生管理副院长
乌克兰国家工程院外籍院士、美国骨与矿物质研究学会(ASBMR)会士、国际华人骨科研究学会(ICMRS)候任主席
0755-88018488
xiaogz@sustech.edu.cn

个人简介

肖国芝现任欧宝ob体育app(中国)有限公司官网,医学院教授、副院长(科研和研究生),乌克兰国家工程院外籍院士,国际华人骨研学会(ICMRS)候任主席,美国骨矿研究学会(ASBMR)会士,深圳市高层次引进人才(孔雀A),广东省细胞微环境与疾病研究重点实验室主任。研究骨骼发育和骨骼疾病 (骨质疏松、骨关节炎及癌症骨转移)的相关分子基础。北京大学医学部博士;美国密歇根大学博士后,讲师,研究助理教授;美国匹茨堡大学医学院助理教授、副教授;美国拉什大学教授、冠名讲席教授(Falk Chair Professor)、生物化学系的研究主任;历任欧宝ob体育app(中国)有限公司官网,生物系系主任、致诚书院院长。主持美国R01、国自然重大、重点、科技部973及重大专项课题。发表SCI文章139篇,书章节等16章/篇, 国际会议摘要85篇,引用13500余次,总影响因子大于1025。主办骨科研究国际会议多次,国际大会及著名大学学术报告180次。国际骨科研究大会获奖10余次。担任J Bone Miner Res及 J Biol Chem等国际学术刊物的编委,担任57个国际杂志的审稿人。担任中国、美国和意大利研究基金评审专家。北京大学医学部(原北京医科大学)100周年校庆,优秀校友。

 

研究领域

(1)研究骨与关节发育及稳态维持的分子机制;

(2)研究骨质疏松症及骨性关节炎发生发展的分子基础;

(3)研究骨机械应力信号传导机制;

(4)研究骨-骨外组织的相互作用。

 

教育背景
1979-1984:南昌大学医学院医疗系,医疗专业,医学学士学位。
1985-1988:北京大学医学部生物化学和分子生物学系,硕士学位。
1991-1994:北京大学医学部生物化学和分子生物学系,博士学位。

 

作经历

2020-          欧宝ob体育app(中国)有限公司官网,医学院科研和研究生管理副院长、教授

2019-2020  欧宝ob体育app(中国)有限公司官网,致诚书院院长

2017-          欧宝ob体育app(中国)有限公司官网,实验动物中心主任

2015-2018   欧宝ob体育app(中国)有限公司官网,生物系系主任

2013-2019   欧宝ob体育app(中国)有限公司官网,生物系教授

2012-2017   美国拉什大学医学中心副教授,正教授、讲席教授、生物化学系科研主任

2005-2011   美国匹兹堡大学医学院,助理教授、终身副教授

1994-2005   美国密歇根大学医学院/牙学院,博士后、讲师、研究助理教授

1988-1991   北京大学医学部, 讲师

1984-1985   江西萍乡妇幼保健院,医生

 

奖情况及荣誉

2012  北京大学医学部(原北京医科大学) 100周年校庆,优秀校友荣誉称号

2015  深圳市鹏城学者

2016  深圳市生命科学与生物技术协会副会长

2017  深圳市海外高层次人才(孔雀A类)

2019  国际骨科研究联合学会,会士

2019  美国骨与矿物质研究学会,会士

2020  欧宝ob体育app(中国)有限公司官网,年度教授奖

2021  国际华人骨科研究学会,候任主席 (International Chinese Musculoskeletal Research Society (ICMRS), President-elect)

2022 爱思唯尔(Elsevier)中国高被引学者 (生物学)(Most Cited Chinese Researchers).

2022 乌克兰国家工程院外籍院士


杂志编委、副主编

2013- Journal of Biological Chemistry (JBC), editorial board member

2009-2015 Journal of Bone and Mineral Research (JBMR), editorial board member

2018- Journal of Orthopaedic Translation (JOT), editorial board member

2020- 生物骨科材料与临床研究杂志,副主编


代表文章

From total 165 publications

  1. Walke W, Xiao G, and Goldman D. A dual function activity-dependent, muscle-specific enhancer from rat nicotinic acetylcholine receptor d-subunit gene. J Neurobiol. 1996; 31(3): 359-369.

  2. Walke W, Xiao G, and Goldman D. Identification and characterization of a 47 base pair activity-dependent enhancer of the rat nicotinic acetylcholine receptor d-subunit promoter. J Neurosci. 1996; 16(11): 3641-3651.

  3. Xiao G, Cui Y, Ducy P, Karsenty G, and Franceschi RT. Ascorbic acid-dependent activation of the osteocalcin promoter in MC3T3-E1 preosteoblasts: requirement for collagen matrix synthesis and the presence of an intact OSE2 sequence. Mol Endocrinol. 1997; 11:1103-1113.

  4. Xiao G, Wang D, Benson MD, Karsenty G, and Franceschi RT. Role of the a2 integrin in osteoblast-specific gene expression and activation of the Osf2 transcription factor. J Biol Chem. 1998; 273, 32988-32994.

  5. Frendo JL, Xiao G, Fuches S, Franceschi RT, Karsentry G, and Ducy P. Functional hierarchy between two OSE2 elements in the control of osteocalcin expression in vivo. J Biol Chem. 1998; 273, 30509-30516.

  6. Wang D, Christensen, K, Chawla, K, Xiao G, Krebsbach P. and Franceschi, RT. Isolation and characterization of MC3T3-E1 murine preosteoblast subclones with distinct in vitro and in vivo differentiation/mineralization potential. J Bone Miner Res. 1999; 14:893-903.

  7. Benson MD, Aubin JE, Xiao G, Thomas PE, and Franceschi RT. Cloning of a 2.5 kb murine bone sialoprotein promoter fragment and functional analysis of putative Cbf/runt binding sites. J Bone Miner Res. 1999; 14:396-405.

  8. Xiao G, Jiang D, Thomas PE, Benson MD, Guan KL, Karsenty G, and Franceschi RT. MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Osf2/Cbfa1. J Biol Chem. 2000; 275, 4453-4459. 

  9. Benson MD, Bargeon JL, Xiao G, Thomas PE, Ahn Kim, Yingqi Cui, and Franceschi RT. Identification of a homeodomain binding element in the bone sialoprotein gene promoter which is required for its osteoblast-selective expression. J Biol Chem. 2000; 275: 13907-13917.

  10. Franceschi RT. Xiao G, Thomas PE, Jiang D, and Benson MD. Extracellular matrix regulation of osteoblast-specific gene expression: role of the a2bintegrin and Osf2/Cbfa1. Chemistry and Biology of Mineralized Tissues: Connect Tissue Res. 2000;41 Suppl 1:249-254.

  11. Ma PX, Zhang R, Xiao G, and Franceschi RT. Engineering new bone tissue in vitro on highly pore poly(-hydroxyl acids)/hydroxyapatite composite scaffolds. J Biomed Mater Res. 2001; 54:284-293.

  12. Xiao G, Jiang D, Gopalakrishnan R, and Franceschi RT. FGF-2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1/Runx2. J Biol Chem. 2002; 277:36181-36187.

  13. Zhao M, Xiao G, Berry J, Franceschi RT, Reddi A, and Somerman MJ. Bone Morphogenetic Protein 2 induces dental follicle cells to differentiate toward a cementoblast/osteoblast phenotype. J Bone Miner Res. 2002; 17:1441-1451. 

  14. Xiao G, Gopalakrishnan R, Jiang D, Reith E, Benson MD, and Franceschi RT. BMP, extracellular matrix, and MAP kinase signaling pathways are required for osteoblast-specific gene expression and differentiation in MC3T3-E1 cells. J Bone Miner Res. 2002; 17:101-110.

  15. Franceschi RT and Xiao G. Regulation of osteoblast-specific transcription factor, Runx2: Responsiveness to multiple signal transduction pathways. J Cell Biochem. 2003; 88:446-454.

  16. Franceschi RT. Xiao G, Jiang D, Gopalakrishnan R, Yang S and Reith E. Multiple signaling pathways converge on the Cbfa1/Runx2 transcription factor to regulate osteoblast differentiation: Connect Tissue Res. 2003;44 Suppl 1:109-16.

  17. Chen C, Koh AJ, Datta NS, Zhang J, Even ET, Xiao G, Franceschi RT, D'Silva NJ, and McCauley LK. Impact of mitogen-activated protein kinase (MAPK) pathway on parathyroid hormone related protein actions in osteoblasts. J Biol Chem. 2004; 279, 29121-29129.

  18. Jiang D, Franceschi RT, Boules H, and Xiao G*. Parathyroid Hormone Induction of the Osteocalcin Gene:requirement for an osteoblast-specific element 1 sequence in the promoter and involvement of multiple signaling pathways. J Biol Chem. 2004; 279:5329-5337.

  19. Xiao G*, Jiang D, Ge C, Zhao Z, Yumei Lai, Boules H, Phimphilai M, Yang X, Karsenty G, and Boules H, and Franceschi RT. Cooperative interactions between activating transcription factor 4 and Runx2/Cbfa1 stimulate osteoblast-specific osteocalcin gene expression. J Biol Chem. 2005; 280:30689-30696.

  20. Roca H, Phimphilai M, Gopalakrishnan R, Xiao G, and Franceschi RT. Cooprative interactions between RUNX2 and homeodomain protein binding sites are critical for the osteoblast-specific expression of the bone sialoprotein gene. J Biol Chem. 2005; 280:30845-30855.

  21. Zhao Z, Zhao M, Xiao G, and Franceschi RT. Gene transfer of the Runx2 transcription factor enhances osteogenic activity of bone marrow stromal cells in vitro and in vivoMol Ther. 2005; 12(2):247-53.

  22. Lu, Y, Cai Z, Galson DL, Xiao G, Liu, Y, George DE, Melhem MF, Yao Z, Zhang J. Monocyte chemotactic protein-1 (MCP-1) acts as a paracrine and autocrine factor for prostate cancer growth and invasion. Prostate. 2006; 66(12): 1311-8.

  23. Franceschi RT, Xiao G. Osteoblasts: Staying the course. Meeting report from the 29th Annual Meeting of the American Society for Bone and Mineral Research. BoneKEy-Osteovision 2006; 4 (12), 327-332.

  24. Zhu J, Jia X, Xiao G, Kang Y, Partridge, NC, Qin L. EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors in osteoblasts: implications in osteolytic bone metastases. J Biol Chem.2007; 282(37): 26656-64.

  25. Franceschi RT, Ge C, Xiao G, Roca H, Jiang D. Transcriptional regulation of osteoblasts. Ann N Y Acad Sci. 2007; 1116:196-207.

  26. Lu Y, Xiao G, Galson DL, Nishio Y, Mizokami A, Keller E, Yao Z, and Zhang J. PTHrP-induced production of monocyte chemoattractant protein-1 (MCP-1) by human bone marrow endothelial cells and osteoblasts promotes osteoclast differentiation in vitro: a novel role in prostate cancer bone metastasis. Int J Cancer. 2007; 121(4): 724-733.

  27. Lu Y, Cai Z, Xiao G, Liu Y, Keller E, Yao Z, and Zhang J. CCR2 expression correlates with prostate cancer progression. J Cell Biochem. 2007; 101(3): 676-85.

  28. Lu Y, Cai Z, Xiao G, Yao Z, Anderson JL, Roodman DG, and Zhang J. Prostate cancer cells induce osteoclastogenesis and bone resorption through RANKL-independent interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) production. Cancer Res. 2007; 67(8): 3646-53.

  29. Ge C, Xiao G, Jiang D, and Franceschi RT. Critical role of extracellular signal-regulated kinase/MAPK pathway in osteoblast differentiation and skeletal development. J Cell Biol. 2007; 176(5): 709-818. PMCID: PMC2064027.

  30. Feng, R, Anderson G, Xiao G, Elliot G, Leoni L, Lapara MY, Roodman GD, and Lentzsch S. SDX-308, a non-steroidal anti-inflammatory agent, inhibits NF-kB activity resulting in strong inhibition of osteoclast formation/activity and multiple myeloma cell growth. Blood. 2007; 109(3): 2130-2138.

  31. Yu S, Franceschi RT, Luo M, Zhang X, Jiang D, Lai Y, Jiang Y, Zhang J, Xiao G. Parathyroid hormone increases activating transcription factor 4 expression and activity in osteoblasts: requirement for osteocalcin gene expressionEndocrinology. 2008; 149(4): 1960-8. PMCID: PMC2276723.

  32. Singha UK, Jiang Y. Yu S, Luo M, Lu Y, Zhang J, Xiao G. Rapamycin inhibits osteoblast proliferation and differentiation in MC3T3-E1 cells and primary mouse bone marrow stromal cells. J Cell Biochem. 2008 Feb 1;103(2):434-46. doi: 10.1002/jcb.21411.PMID: 17516572。

  33. Chen D, Xiao G, Zhang M, Xing L, and Jonason JH. Post-translational regulation of Runx2 in bone cells. J Dent Res. 2008; 88(8): 693-703.

  34. Franceschi RT, Ge C, Xiao G, Roca H, Jiang D. Transcriptional regulation of osteoblasts. Cells Tissues Organs. 2009;189(1-4):144-152.

  35. Yu S, Jiang Y, Galson DL, Luo M, Lai Y, Lu Y, Ouyang HJ, Zhang J, Xiao G. General transcription factor IIA-gamma increases
osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runt-related transcription factor 2. J Biol Chem.  2008; 283(9): 5542-53. PMCID: PMC2736298.

  36. Zhang X, Yu S, Galson, DL, Luo M, Fan J, Zhang J, Guan Y, Xiao G. Activating
transcription factor 4 is critical for proliferation and survival in primary bone marrow stromal cells and calvarial osteoblasts. J Cell Biochem. 2008; 105(3): 885-95. PMCID: PMC2704124.

  37. Liu Y, Yuan Y, Li Y, Zhang J, Xiao G, Vodovotz Y, Billiar TR, Wilson M, Fan J. Interacting neuro-endocrine, innate, and acquired immune pathways regulate neutrophil from bone marrow following hemorrhage shock. J Immnol. 2009;182(1):572-580. PMCID: PMC2610356.

  38. Cai, Z, Chen Q, Chen J, Lu Y, Xiao G, Wu Z, Zhou Q, Zhang J. Monocyte chemotactic protein-1 promotes lung cancer-induced bone resorptive lesion in vivo. Neoplasia. 2009;11(3):228-36. PMCID: PMC2647725.

  39. Yu S, Franceschi RT, Luo M, Fan J, Jiang D, Cao H, Lai Y, Zhang J, Patrene K, Hankenson KD, Roodman GD, Xiao G. Critical role of activating transcription factor 4 in the anabolic actions of PTH in bone. PLoS One. 2009, Oct 23;4(10):e7583. PMCID: PMC2762317. (This paper was listed as the "Not to be Missed" paper in the November (2009) issue of the IBMS BoneKEy. BoneKEy is published by the International Bone & Mineral Society).

  40. Ge C, Xiao G (co-first author), Jiang D, Yang Q, Hatch NE, and Franceschi RT. Identification and functional characterization of extracellular-regulated kinase/MAPK phosphorylation sites in the Runx2 transcription factor. J Biol Chem. 2009; 284(47):32533-43. PMCID: PMC2781667.

  41. Li Y, Xiang M, Yuan Y, Xiao G, Zhang J, Vodovotz Y, Billiar TR, Wilson MA, and Fan J. HMGB1 upregulation of TLR2 augments hemorrhagic shock-Induced ICAM-1 expression in lung endothelial cells. Am J Physiol Regul Integr Comp Physiol. 2009; 297(6):R1670-80, PMCID: PMC2803625.

  42. Cao H, Yu S, Yao Z, Galson DL, Jiang Y, Zhang X, Fan J, Lu B, Guan Y, Luo M, Lai Y, Zhu, Y, Kurihara N, Patrene K, Roodman GD, Xiao G. Activating transcription factor 4 regulates osteoclast differentiation in mice. J Clin Invest. 2010 Aug 2;120(8):2755-66. PMCID: PMC2912190.

  43. Wu, Z, Jiao P, Huang, X, Feng Y, Feng B, Yang S, Hwang P, Du J, Hall RK, Xiao G, Xu H. MAP kinase phosphatase 3 regulates glucose homeostasis through dephosphorylation of FOXO1 in mice. J Clin Invest. 2010 Nov 1;120(11):3901-11. PMCID: PMC2964981.

  44. Xiang M, Yin L, Li Y, Xiao G, Vodovotz Y, Billiar TR, Wilson MA, and Fan J. Hemorrhagic shock activates lung endothelial NAD(P)H oxidase via neutrophil NADPH oxidase. Am J Respir Cell Mol Biol. 2011 Mar;44(3):333-40. PMCID: PMC3095934.

  45. Yang S, Xu H, Yu S, Cao H, Jie Fan, Ge C, Fransceschi RT, Dong HH, Xiao G. Foxo1 mediates IGF1/Insulin regulation of osteocalcin expression by antagonizing Runx2 in osteoblasts. J Biol Chem. 2011; 286(21):19149-58. PMCID: PMC3099728.

  46. Xiang M, Shi X, Li Y, Xu J, Yin L, Xiao G, Scott MJ, Billiar TR, Wilson MA, and Fan J. Hemorrhagic shock activation of NLRP3 inflammasome in lung endothelial cells. J Immnol. 2011; 187(9) :4809-17, PMCID: PMC3197874.

  47. Danciu TH, Li Y, Koh A, Xiao G, McCauley LK, Franceschi RT. The basic helix loop helix transcription factor Twist1 is a novel regulator of ATF4 in osteoblasts. J Cell Biochem. 2011;113(1):70-9. PMCID: PMC3414260.

  48. D'Souza S, Del Prete D, Jin S, Sun Q, Huston AJ, Kostov FE, Sammut B, Hong CS, Anderson JL, Patrene KD, Yu S, Velu CS, Xiao G, Grimes HL, Roodman GD, Galson DL. Gfi-1 expressed in bone marrow stromal cells is a novel osteoblast suppressor in patients with multiple myeloma bone disease. Blood. 2011;118(26):6871-80. PMCID: PMC3245209.

  49. Tang W, Yang F, Li Y, de Crombrugghe B, Jiao H, Xiao G, and Zhang C. Transcriptional regulation of vascular endothelial growth factor (VEGF) by osteoblast-specific transcription factor osterix (Osx) in osteoblasts. J Biol Chem. 2012 Jan 13;287(3):1671-8. PMCID: PMC3265850.

  50. Xiang M, Yuan Y, Fan L, Li Y, Li A, Yin L, Scott MJ, Xiao G, Billiar TR, Wilson MA, Fan J. Role of Macrophages in Mobilization of Hematopoietic Progenitor Cells From Bone Marrow After Hemorrhagic Shock. Shock. 2012 May;37(5):518-523. PMCID: PMC3328610.

  51. Li X, Ellman MB, Kroin JS, Chen D, Yan D, Mikecz K, Kc R, Xiao G, Stein GS, Kim SG, Cole B, van Wijnen AJ, Im HJ. Species-specific biological effects of FGF-2 in articular cartilage: Implication for distinct roles within the FGF receptor family. J Cell Biochem. 2012 Jul;113(7):2532-42. PMCID: PMC3349778.

  52. Xiao G*, Cheng H, Cao H, Chen K, Tu Y, Yu S, Jiao H, Yang S, Im HJ, Chen D, Chen J, Wu C*. Critical role of Filamin-binding LIM protein 1 (FBLP-1)/migfilin in regulation of bone remodeling. J Biol Chem. 2012 June 15;287(25):21450-60. PMCID: PMC3375566.

  53. Ellman MB, Kim JS, An HS, Chen D, Ranjan KC, An J, Dittakavi T, van Wijnen AJ, Cs-Szabo G, Li X, Xiao G, An S, Kim SG, Im HJ. Toll-like receptor adaptor signaling molecule MyD88 on intervertebral disc homeostasis: in vitro, ex vivo studies. Gene. 2012 Sep 1;505(2):283-90, PMCID: PMC3518428.

  54. Yan D, Chen D, Xiao G, van Wijnen A, Im HJ. Bovine lactoferricin, an antimicrobial peptide, is anti-inflammatory and anti-catabolic in human articular cartilage and synovium. J Cell Physiol. 2013 Feb;228(2):447-56, PMCID: PMC3463726.

  55. Meng M, Jin H, Wang B, Yukata K, Sheu TJ, Ke QH, Tong P, Im HJ, Xiao G, Chen D. Chondrocyte BMP-2 Signaling Plays a Critical Role in Bone Fracture Healing. Gene. 512 (2013) 211–218. PMCID: PMC3531824.

  56. Yu S, Sharma R, Nie D, Jiao H, Lai Y, Fan J, Im HJ, Chen D, Wang Q, Xiao G. ADAR1 is required for osteoblast differentiation and bone homeostasis. Gene. 513 (2013) 101–110. PMCID: PMC3514579.

  57. Yu S, Zhu K, Lai Y, Zhao Z, Fan J, Im HJ, Chen D, Xiao G. ATF4 promotes β-catenin expression and osteoblastic differentiation of bone marrow mesenchymal stem cells. Int J Biol Sci. 2013; 9(3):256-266. PMCID: PMC3596711.

  58. Xu P, Wen Z, Shi X, Li Y, Fan L, Xiang M, Li A, Scott MJ, Xiao G, Li S, Billiar TR, Wilson MA, Fan J. Hemorrhagic shock augments Nlrp3 inflammasome activation in the lung through impaired pyrin induction. J Immunol. 2013 May 15;190(10):5247-55. PMCID: PMC3646900.

  59. Kim JS, Ellman MB, Yan D, An HS, Kc R, Li X, Chen D, Xiao G, Cs-Zabo G, Hoskin DW, Buechter DD, van Wijnen AJ, Im HJ. Lactoferricin mediates anti-inflammatory and anti-catabolic effects via inhibition of IL-1 and LPS activity in the intervertebral disc. J Cell Physiol. 2013 Sep;228(9):1884-96. PMCID: PMC3703102.

  60. Ellman MB, Kim J, An HS, Chen D, Kc R, Li X, Xiao G, Yan D, Suh J, van Wijnen A, Wang J, Kim S, Im H. Lactoferricin enhances BMP7-stimulated anabolic pathways in intervertebral disc cells. Gene. 2013 Jul 25;524(2):282-91. PMCID: PMC3679319.

  61. Liu Z, Jiang Y, Li Y, Wang J, Fan L, Scott MJ, Xiao G, Li S, Billiar TR, Wilson MA, Fan J. TLR4 signaling augments monocyte chemotaxis by regulating G protein-coupled receptor kinase 2 translocation. J Immunol. 2013 Jul 15;191(2):857-64. PMCID: PMC3702632.

  62. Zheng L, Zhu K, Jiao H, Zhao Z, Zhang L, Liu M, Chen D, Yao Z, Xiao G. PTHrP expression in human MDA-MB-231 breast cancer cells is critical for tumor growth and survival and osteoblast inhibition. Int J Biol Sci. 2013 Aug 21;9(8):830-41. PMCID: PMC3753447.

  63. Xiao G*, Zhang T, Yu S, Lee A, Calabuig-Navarro V, Ringquist S, Dong HH*. ATF4 deficiency protects against high fructose-induced hypertriglyceridemia in mice.  J Biol Chem. 2013 Aug 30;288(35):25350-61. PMCID: PMC3757199.

  64. Zhu K, Jiao H, Li S, Cao H, Galson DL, Zhao Z, Zhao X, Lai Y, Fan J, Im HJ, Chen D, Xiao G. ATF4 promotes bone angiogenesis by increasing VEGF expression and release in the bone environment. J Bone Miner Res.2013;28: 1870–1884. PMID: 23649506. This is an EDITOR'S CHOICE paper of September 2013 JBMR issue and highlighted with a Commentary paper ( Schipani et al. J Bone Miner Res. 2013;28:1866-1869. DOI: 10.1002/jbmr.2045).

  65. Cao H, Zhu K, Qiu L, Li S, Niu H, Hao M, Yang S, Zhao Z, Lai Y, Anderson JL, Fan J, Im HJ, Chen D, Roodman GD, Xiao G. Critical role of AKT in myeloma-induced osteoclast formation and osteolysis. J Biol Chem. 2013 Oct 18;288(42):30399-410. PMCID: PMC3798504.

  66. Yan D, Kc R, Chen D, Xiao G, Im H. Bovine lactoferricin-induced anti-inflammation is, in part, via upregulation of IL-11 by secondary activation of STAT3 in human articular cartilage. J Biol Chem. 2013 Nov 1;288(44):31655-69. PMID: 24036113.

  67. Wang B, Jin H, Zhu M, Li J, Zhao L, Zhang Y, Tang D, Xiao G, Xing L, Boyce BF, Chen D Chondrocyte β-catenin signaling regulates postnatal bone remodeling through modulation of Rankl/Opg expression and osteoclast differentiation. Arthritis Rheumatol. 2014 Jan;66(1):107-20. doi: 10.1002/art.38195. PMID: 244312822.

  68. Li TF, Yukata K, Yin G, Sheu T, Maruyama T, Jonason JH, Hsu W, Zhang X, Xiao G, Konttinen YT, Chen D, O'Keefe RJ. BMP-2 regulates chondrocyte differentiation through modulation of COX-2 and ATF4. Osteoarthritis Cartilage. 2014 Mar;22(3):481-9. PMID: 24418675.

  69. Li S, Shu B, Zhang Y, Li J, Guo J, Wang Y, Ren F, Xiao G, Chang Z, Chen D. CHIP regulates osteoclast formation through promoting TRAF6 protein degradation. Arthritis Rheumatol. 2014 Jul;66(7):1854-63. doi: 10.1002/art.38521. PMID: 24578159.

  70. Xu J, Jiang Y, Wang J, Shi X, Liu Q, Liu Z, Li Y, Scott MJ, Xiao G, Li S, Fan L, Billiar TR, Wilson MA, Fan J. Macrophage endocytosis of high-mobility group box 1 triggers pyroptosis. Cell Death Differ. 2014 Aug;21(8):1229-39. PMID: 24769733. PMCID: PMC4085529.

  71. Qu H, Tu Y, Guan JL, Xiao G, Wu C. Kindlin-2 tyrosine phosphorylation and interaction with Src serve as a regulatable switch in the integrin outside-in signaling circuit. J Biol Chem. 2014 Nov 7;289(45):31001-13. PMID: 2523719.

  72. Wen Z, Fan L, Li Y, Zou Z, Scott MJ, Xiao G, Li S, Billiar TR, Wilson MA, Shi X, Fan J. Neutrophils counteract autophagy-mediated anti-inflammatory mechanisms in alveolar macrophage: role in posthemorrhagic shock acute lung inflammation. J Immunol. 2014 Nov 1;193(9):4623-33. PMID: 25267975.

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实验室获奖:

· Guozhi Xiao, ASBMR (American Society for Bone and Mineral Research) Annual Meeting, Travel Award, 1996

· Guozhi Xiao, ASBMR Young Investigator Award, 1998

· Shibing Yu, 5th Research Day, Department of Medicine, University of Pittsburgh, First Award of Post-Doc Fellow Category, 2007

· 曹惠玲, 教育部博士论文百优提名, 2010

· Huiling Cao, ICBMR/IOS (9th International Conference on Bone and Mineral Research (ICBMR) & 11th International Osteoporosis Symposium) Young Investigator Award, 2011

· Huiling Cao, ASBMR Young Investigator Award, 2011

· Guozhi Xiao, International Chinese Musculoskeletal Research Conference (ICMRC), Best Poster Presentation Award, 2013

· Shibing Yu, ASBMR Travel Award, Plenary Poster, 2013

· Ke Zhu, ASBMR Travel Award, Plenary Poster, 2014

· Huiling Cao, ASBMR Travel Award, Plenary Poster, 2016

· Xin Liu, ASBMR Travel Award, Plenary Poster, 2017

· Xin Liu, ICMRS, First Young Investigator Prize, oral presentation, 2017

· Huiling Cao, ICMRS, First Young Investigator Prize, oral presentation, 2017

· Huiling Cao, ASBMR, Plenary Poster, 2017

· Huiling Cao, ICMRS Webster Jee Travel Award, 2018

· Yishu Wang, ASBMR Young Investigator Award, Oral Presentation, 2019

· 王依姝,博士研究生国家奖学金, 2019

· Yiming Lei, ASBMR Education Emerging Country Young Investigator Award,2019

· Yiming Lei, ICMRS, Third Young Investigator Prize, oral presentation, 2019

· Lei Qin, ICMRS, First Young Investigator Prize, oral presentation, 2019

· 刘鑫, 校十佳毕业生候选人,校级优秀毕业生, 2019

· 郭禺熙, 生物系优秀毕业生, 2020

· 李茹璇, 校十佳毕业生候选人, 校级优秀毕业生, 2020

· 李鹏宇, 生物系优秀毕业生, 2020

· 肖国芝,欧宝ob体育app(中国)有限公司官网,,年度教授奖, 2020

· 曹惠玲, 国自然优秀青年基金获得者, 2020

· Lei Qin, ASBMR Young Investigator Award, 2021

· Xiaohao Wu, ASBMR Felix Bronner Young Investigator Award; the highest ranking abstract, 2021

· Xiaohao Wu, ICMRS Webster Jee Young Investigator Award, 2021

· 陈明珏,硕士研究生国家奖学金,2021

· 高焕庆,首届欧宝ob体育app(中国)有限公司官网,医学系统学术年会,一等奖, 2021

· 吴晓昊,首届欧宝ob体育app(中国)有限公司官网,医学系统学术年会,三等奖, 2021

· 陈胜,首届欧宝ob体育app(中国)有限公司官网,医学系统学术年会,优秀奖,2021

· 姚青, 国自然面上基金, 53万,2022

· 河泰麟,欧宝ob体育app(中国)有限公司官网,医学院,优秀博士生,2022

· 陈明珏,欧宝ob体育app(中国)有限公司官网,医学院,优秀研究生,2022

· 钟一鸣,欧宝ob体育app(中国)有限公司官网,医学院“院长奖”,2022

· 河泰麟,欧宝ob体育app(中国)有限公司官网,医学院2021度优秀研究生,2022

· 钟一鸣,欧宝ob体育app(中国)有限公司官网,校级硕士学位论文,2022

· 钟一鸣,欧宝ob体育app(中国)有限公司官网,校级优秀研究生毕业生,2022

· 钟一鸣,欧宝ob体育app(中国)有限公司官网,2022年研究生“十佳毕业生”

· 甘东浩,教育部博士后基金, 8万,2022

· 陈明珏, ICMRS Webster Jee Young Investigator Award, 2022